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Liver cirrhosis in HIV/HCV ‐coinfected individuals is related to NK cell dysfunction and exhaustion, but not to an impaired NK cell modulation by CD 4 + T‐cells
(BioMed Central, 2019-09)
Introduction HIV worsens HCV‐related liver disease by accelerating fibrosis progression; however, progression rates are extremely variable among HIV/HCV‐coinfected individuals. NK cells are associated with modulation of ...
Cetuximab and IL-15 Promote NK and Dendritic Cell Activation In Vitro in Triple Negative Breast Cancer
(MDPI AG, 2020-06)
Triple Negative Breast Cancer (TNBC) treatment is still challenging, and immunotherapy is a potential approach in this tumor subtype. Cetuximab is an IgG1 monoclonal antibody (mAb) directed against Epidermic Growth Factor ...
NK cell-derived IL-10 is critical for DC-NK cell dialogue at the maternal-fetal interface
(Nature Publishing Group, 2017-12)
DC-NK cell interactions are thought to influence the development of maternal tolerance and de novo angiogenesis during early gestation. However, it is unclear which mechanism ensures the cooperative dialogue between DC and ...
Regulatory Dendritic Cells restrain NK cell IFN-g production through mechanisms involving NKp46, IL-10 and MHC class I-specific inhibitory receptors
(Amer Assoc Immunologists, 2015-09-01)
Cross-talk between mature dendritic cells (mDC) and NK cells through the cell surface receptors NKp30 and DNAM-1 leads to their reciprocal activation. However, the impact of regulatory dendritic cells (regDC) on NK cell ...
Tumor-Experienced Human NK Cells Express High Levels of PD-L1 and Inhibit CD8+ T Cell Proliferation
(Frontiers Media SA, 2021-09)
Natural Killer (NK) cells play a key role in cancer immunosurveillance. However, NK cells from cancer patients display an altered phenotype and impaired effector functions. In addition, evidence of a regulatory role for ...
NK cells expressing a progesterone receptor are susceptible to progesterone-induced apoptosis
(American Association of Immunologists, 2008-04-15)
It has been proposed that progesterone (P4) induces the suppression of immune responses, particularly during pregnancy. However, knowledge about the mechanisms involved has remained largely elusive. We demonstrate herein ...
Characterization of tachykinin NK2 receptor in the anterior pituitary gland
(Pergamon-Elsevier Science Ltd, 2003-09)
Tachykinins are a family of bioactive peptides that interact with three subtypes of receptors: NK1, NK2 and NK3. Substance P has greater affinity for NK1, and neurokinin A (NKA) for NK2 receptor subtype. Although only NK1 ...
NK cells restrain spontaneous antitumor CD8+ T cell priming through pd-1/pd-l1 interactions with dendritic cells
(American Association of Immunologists, 2016-08)
Despite the classical function of NK cells in the elimination of tumor and of virus-infected cells, evidence for a regulatory role for NK cells has been emerging in different models of autoimmunity, transplantation, and ...
Altered phenotype in peripheral blood and tumor-associated NK cells from colorectal cancer patients
(Sage Publications Ltd, 2013-02)
Despite NK cells being originally identified because of their ability to kill tumor cells in vitro, only limited information is available on NK cells infiltration of malignant tumors, especially in humans. NK cells ...
Altered Glycosylation Contributes to Placental Dysfunction Upon Early Disruption of the NK Cell-DC Dynamics
(Frontiers Media, 2020-07)
Immune cells [e. g., dendritic cells (DC) and natural killer (NK) cells] are critical players during the pre-placentation stage for successful mammalian pregnancy. Proper placental and fetal development relies on balanced ...